To prescribe TPE the amount of plasma to be exchanged must be determined in relation to the patient’s estimated plasma volume (EPV). This calculator uses this formula to calculate the EPV from the patient’s weight and hematocrit:
Estimated plasma volume (EPV) = (weight x 65) x (1- hematocrit/100)
Volume to be exchanged= EPV x number of plasma exchanges
PMID: 23420589.
PMID: 36775691
ONE SESSION KINETICS:
The amount of plasma to be exchanged to provide a given reduction in pretreatment levels of macromolecules can be determined by application of first-order kinetics using the formula:
Macromolecule reduction ratio= (1 - (Math.exp (-number of plasma exchange))) * 100
Macromolecule residual proportion = (Math.exp(-number of plasma exchange)) * 100
This applies only for one session and only for intravascular pretreatment level reductions
TOTAL TREATMENT IgG KINETICS:
A 21 days preformed IgG pool will be reduced after a number of specific TPE treatments, this calculator assumes no IgG synthesis, an IgG distribution of 45% intravascular, 55% extravascular and a complete equilibrium of IgG between TPE treatments.
This specific calculator does not apply to other macromolecules including IgG3
PMID: 23420589.
The amount of albumin vials to prepare an albumin replacement solution can be practical information for a proper prescription. This calculator uses simple calculations to determine the number of vials according to the initial albumin percentage, the volume of preparation and desire final albumin percentage:
Number of 25% vials = Initial concentration x ( preparationVolume / 100) / 12.5
Number of 20% vials = Initial concentration x ( preparationVolume / 100) / 10
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Disclaimer: Extracorporeal therapies are complex and need full understanding of technical and clinical issues. Adequator is no substitute for technical and clinical reasoning. No medical decision should be made solely on results of this program.