Estimated as a function of blood flow (Qb), dialysate flow (Qd) and membrane permeability area coefficient (koA) using the proposed model by Michales and modified by Depner et al.
The product of estimated urea clearance (K) and therapy time divided by the estimated urea volume of distribution (V). The urea V is the total body water calculated with the Watson formula.
Solved from the previous estimated Kt/V as: URR = 1- (eKt/V)
Daugirdas JT, Leypoldt JK, Akonur A, Greene T, Depner TA; FHN Trial Group. Improved equation for estimating single-pool Kt/V at higher dialysis frequencies. Nephrol Dial Transplant. 2013 Aug;28(8):2156-60.
BUN, sodium and potassium have similar mass transfer during hemodialysis, so when considering a one compartment model the new concentration is: Pre therapy solute - [(Solute blood - Solute dialysate) * URR]
These results have been validated in a prospective cohort pending publication
Disclaimer: Extracorporeal therapies are complex and need full understanding of technical and clinical issues. Adequator is no substitute for technical and clinical reasoning. No medical decision should be made solely on results of this program.